期刊论文详细信息
Anais da Academia Brasileira de Ciências
Antioxidant potential and cytotoxic activity of two red seaweed species, Amansia multifida and Meristiella echinocarpa, from the coast of Northeastern Brazil
Daniel B. De Alencar1  Suzete R. Da Silva1  Kelma M.s. Pires-cavalcante1  Rebeca L. De Lima1  Francisco N. Pereira JÚnior1  MÁrcia B. De Sousa1  Francisco A. Viana1  Celso S. Nagano1  Kyria S. Do Nascimento1  Benildo S. Cavada1  Alexandre H. Sampaio1  Silvana Saker-sampaio1 
关键词: antioxidant;    bioactive compounds;    cytotoxic;    phenolic compounds;    Rhodophyta;    antioxidante;    substâncias bioativas;    citotóxico;    compostos fenólicos;    Rhodophyta;   
DOI  :  10.1590/0001-37652014116312
来源: SciELO
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【 摘 要 】

Natural antioxidants found in marine macroalgae are bioactive compounds known to play an important role in the prevention of diseases associated with aging cells protecting them against the oxidative damage. The purpose of this study was to evaluate the antioxidant and cytotoxic activity of ethanolic extracts of two species of red seaweeds, Amansia multifida and Meristiella echinocarpa. In vitro antioxidant activity was determined by DPPH radical scavenging assay, ferric-reducing antioxidant power (FRAP) assay, ferrous ion chelating (FIC) assay, β-carotene bleaching (BCB) assay and total phenolic content (TPC) quantification. Cytotoxicity was evaluated with the brine shrimp Artemia sp. lethality test. The TPC values observed in the present study indicated that both species A. multifida and M. echinocarpa are rich in phenolic compounds, reaching values of 45.40 and 28.46 mg gallic acid equivalent (GAE) g−1 of ethanolic extract, respectively. DPPH radical scavenging and ferrous ion chelating showed values of 60% and 17%, respectively. Both seaweed extracts inhibited β-carotene oxidation by approximately 40%. None of the algal extracts were potentially cytotoxic. The results have showed that extracts of both species of marine red algae exhibit antioxidant potential and low toxicity. They are sources of natural antioxidant compounds.

【 授权许可】

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