Evaluation of analgesic and anti-inflammatory activities of Hydrocotyle umbellata L., Araliaceae (acariçoba) in mice

Anais da Academia Brasileira de Ciências

Iziara F. Florentino¹  Marcus VinÍcius M. Nascimento¹  Pablinny M. Galdino¹  Adriane F. De Brito¹  Fabio F. Da Rocha¹  Carlos R. Tonussi¹  Thereza Christina M. De Lima¹  JosÉ R. De Paula¹  Elson A. Costa¹ 

关键词: Acariçoba;    anti-inflammatory;    antinociceptive;    Biomedical Sciences;    Hydrocotyle umbellata L;    Acariçoba;    anti-inflamatório;    antinociceptivo;    Ciências Biomédicas;    Hydrocotyle umbellata L;   

DOI  :  10.1590/S0001-37652013000300011

来源: SciELO

【 摘 要 】

The Hydrocotyle umbellata L. is a specimen of the Araliaceae family popularly known as acariçoba. Its indications in folk medicine include treatment of skin ulcers, and rheumatism. The aim of this study was to evaluate the antinociceptive and anti-inflammatory activities of the ethanolic extract from acariçoba's underground parts (EEA). EEA reduced the nociceptive response of the animals as evaluated in the acetic acid-induced writhing test and in both phases of formalin test. EEA also presented a supraspinal analgesic activity by increasing the pain latency in the hot plate test. Moreover, EEA reduced the leukocytes migration and plasma extravasation to pleural cavity in the carrageenan-induced pleurisy, besides reducing the edema induced by carrageenan until the second hour and also the edema induced by dextran. In conclusion our results showed that EEA of H. umbellata L. presents analgesic and anti-inflammatory activities, and that a blockade of activity or reduction in the release of different mediators, such as histamine and serotonin, could be involved in these pharmacologic effects.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License