Essential oil of Mitracarpus frigidus as a potent source of bioactive compounds

Anais da Academia Brasileira de Ciências

Rodrigo L. Fabri²  Elaine S. Coimbra¹  Ana C. Almeida¹  Ezequias P. Siqueira¹  Tânia M.a. Alves¹  Carlos L. Zani¹  Elita Scio² 

[1] ,Universidade Federal de Juiz de Fora Instituto de Ciências Biológicas Departamento de BioquímicaJuiz de Fora MG ,Brasil

关键词: Mitracarpus frigidus;    essential oil;    antimicrobial;    antileishmanial;    cytotoxicity;    Mitracarpus frigidus;    óleo essencial;    antimicrobiano;    leishmanicida;    citotoxidade;   

DOI  :  10.1590/S0001-37652012000400021

来源: SciELO

【 摘 要 】

In our previous work (Fabri et al. 2009), we showed that different extracts of Mitracarpus frigidus had significant antibacterial, antifungal and leishmanicidal activities. In order to increase our knowledge about this species, this work assesses the chemical composition and the in vitro biological activity of its essential oil. Thus, the essential oil obtained by hydrodistillation of the aerial parts of M. frigidus was analyzed by GC/MS. Among several compounds detected, 11 were identified, being linalool and eugenol acetate the major components. The essential oil exhibited a moderate antibacterial effect against Staphyloccocus aureus, Bacillus cereus, Pseudomonas aeruginosa and Enterobacter cloacae (MIC 250 µg/mL). On the other hand, it showed a strong antifungal effect against Cryptoccocus neoformans (MIC 8 µg/mL) and Candida albicans (MIC 63 µg/mL). Expressive activity against L. major and L. amazonensis promastigote forms with IC50 values of 47.2 and 89.7 µg/mL, respectively, were also observed. In addition, the antioxidant activity was investigated through DPPH radical-scavenging and showed a significative activity with IC50 of 38 µg/mL. The cytotoxicity against Artemia salina was moderate with LC50 of 88 µg/mL. The results presented here are the first report on the chemical composition and biological properties of M. frigidus essential oil.

【 授权许可】

CC BY   
 All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License