Removal of the cortical projections alters expression of NOS in the different cell types of the superficial layers of the superior colliculus in rats

Anais da Academia Brasileira de Ciências

Frank TenÓrio²  Arthur Giraldi-guimarÃes¹  Rosalia Mendez-otero¹ 

[1] ,UERJ Instituto de Biologia Roberto Alcântara Gomes Departamento de Farmacologia e PsicobiologiaRio de Janeiro,Brazil

关键词: superior colliculus;    nitric oxide;    visual cortex;    NADPH-diaphorase;    colículo superior;    óxido nítrico;    córtex visual;    NADPH-diaforase;   

DOI  :  10.1590/S0001-37652002000400008

来源: SciELO

【 摘 要 】

Nitric oxide has several biological roles and nitric oxide synthase (NOS) is expressed in the nervous system, and co-localizes with NADPH-diaphorase. The superficial layers of the superior colliculus (SC), which receive retinal and cortical inputs, present NADPH-d staining in a sub-population of neurons that include all cell types. We have previously shown, by NADPH-diaphorase, that eye enucleation alters the intracellular distribution of NOS. Here, we studied the effect of cortical ablation on NOS expression by neurons in collicular superficial layers. Our results show that cortical ablation alters the proportion of different NOS-positive cell types, but not the intracellular distribution of the enzyme.

【 授权许可】

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