Physiopathological modulators of amyloid aggregation and novel pharmacological approaches in Alzheimer's disease

Anais da Academia Brasileira de Ciências

Fernanda G. Defelice¹  SÉrgio T. Ferreira¹ 

[1] ,Federal University of Rio de Janeiro Institute of Biomedical Sciences Department of Medical BiochemistryRio de Janeiro RJ ,Brazil

关键词: Alzheimer's disease;    Abeta peptide;    aggregation;    neurotoxicity;    physiopathological modulators;    doença de Alzheimer;    peptídeo Abeta;    agregação;    neurotoxicidade;    moduladores fisiopatológicos;   

DOI  :  10.1590/S0001-37652002000200006

来源: SciELO

【 摘 要 】

The biological mechanisms underlying the neuropathology of Alzheimer's disease (AD) are complex, as several factors likely contribute to the development of the disease. Therefore, it is not surprising that a number of different possible therapeutic approaches addressing distinct aspects of this disease are currently being investigated. Among these are ways to prevent amyloid aggregation and/or deposition, to prevent neuronal degeneration, and to increase brain neurotransmitter levels. Here, we discuss possible roles of endogenous modulators of Abeta aggregation in the physiopathology of AD and some of the strategies currently under consideration to interfere with brain levels of beta-amyloid, its aggregation and neurotoxicity.

【 授权许可】

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