Molecular Cancer | |
The microbiota and microbiome in pancreatic cancer: more influential than expected | |
Xian-Jun Yu1  Qing-Cai Meng1  Jie Hua1  Yi-Yin Zhang1  Jin Xu1  Bo Zhang1  Si Shi1  Jiang Liu1  Miao-Yan Wei1  Chen Liang1  | |
[1] 0000 0004 1808 0942, grid.452404.3, Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 200032, Shanghai, China;0000 0004 0619 8943, grid.11841.3d, Department of Oncology, Shanghai Medical College, Fudan University, 200032, Shanghai, China;0000 0001 0125 2443, grid.8547.e, Pancreatic Cancer Institute, Fudan University, 200032, Shanghai, China;0000 0004 1808 0942, grid.452404.3, Shanghai Pancreatic Cancer Institute, 200032, Shanghai, China; | |
关键词: Pancreatic cancer; Microbiota; Microbiome; Inflammation; Metabolism; Immunotherapy; Tumor Microenvironment; | |
DOI : 10.1186/s12943-019-1008-0 | |
来源: publisher | |
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【 摘 要 】
Microbiota is just beginning to be recognized as an important player in carcinogenesis and the interplay among microbes is greater than expected. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease for which mortality closely parallels incidence. Early detection would provide the best opportunity to increase survival rates. Specific well-studied oral, gastrointestinal, and intrapancreatic microbes and some kinds of hepatotropic viruses and bactibilia may have potential etiological roles in pancreatic carcinogenesis, or modulating individual responses to oncotherapy. Concrete mechanisms mainly involve perpetuating inflammation, regulating the immune system-microbe-tumor axis, affecting metabolism, and altering the tumor microenvironment. The revolutionary technology of omics has generated insight into cancer microbiomes. A better understanding of the microbiota in PDAC might lead to the establishment of screening or early-stage diagnosis methods, implementation of cancer bacteriotherapy, adjustment of therapeutic efficacy even alleviating the adverse effects, creating new opportunities and fostering hope for desperate PDAC patients.
【 授权许可】
CC BY
【 预 览 】
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