期刊论文详细信息
Drug Delivery
Poly(3-hydroxybutyrate-CO-3-hydroxyvalerate) PHBHV biocompatible nanocarriers for 5-FU delivery targeting colorectal cancer
Ionut Cristian Radu1  Catalin Zaharia1  Horia Iovu1  Marieta Costache2  Ariana Hudita2  Bianca Galateanu2  Kelly Velonia3  Mikhail Shtilman4  Octav Ginghina5  Aristidis Tsatsakis6  Carolina Negrei7  Sabina Georgiana Nitu8  Eugenia (Vasile) Tanasa9 
[1] Advanced Polymer Materials Group, University Politehnica of Bucharest, Bucharest, Romania;Department of Biochemistry and Molecular Biology, University of Bucharest, Bucharest, Romania;Department of Materials Science and Technology, University of Crete, Heraklion, Greece;Department of Polymers, D.I. Mendeleyev University of Chemical Technology, Moscow, Russi;Department of Surgery, Sf. Ioan Emergency Clinical Hospital, Bucharest, Romania;Department II, Faculty of Dental Medicine, Carol Davila University of Medicine and Pharmacy Bucharest, Bucharest, Romania;Department of Toxicology and Forensic Sciences, Faculty of Medicine, University of Crete, Heraklion, Greece;Department of Toxicology, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, Bucharest;National Research and Development Institute for Chemistry and Petrochemistry – ICECHIM, Bucharest, Romania;University Politehnica of Bucharest, Bucharest, Romania;
关键词: Nanocarrier;    5-FU;    polyhydroxyalkanoate;    HT-29;    colorectal cancer;    anticancer efficacy;   
DOI  :  10.1080/10717544.2019.1582729
来源: publisher
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【 摘 要 】

Aiming to address the issue of poor bioavailability of most anti-tumor medicines against colorectal cancer, we developed a targeted anticancer nanocarrier using biocarriers able to both bind and easily release their load in a controlled manner. Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) carriers were obtained via the emulsification-diffusion method, loaded with 5-fluorouracil and then characterized in terms of particle morphology and size (SEM, DLS), drug uptake and release. The cytotoxic potential of the 5-fluorouracil-loaded polymer nanocarriers on human adenocarcinoma cells (HT-29 cell line) was investigated. The in vitro studies clearly demonstrated that while the nanocarriers themselves slightly alter HT-29 cell viability, when loaded with 5-fluorouracil they significantly decrease cell viability, suggesting that the polymer itself exhibits low cytotoxicity and the drug-loaded carrier acts in an efficient manner to kill HT-29 human adenocarcinoma cells.

【 授权许可】

CC BY   

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