Peritoneal carcinomatosis index predicts survival in colorectal patients undergoing HIPEC using oxaliplatin: a retrospective single-arm cohort study

World Journal of Surgical Oncology

Pierre Dubé¹  Lucas Sideris¹  Marie-Eve Aubé Lecompte¹  Nora Trabulsi¹  Bertrand Trilling¹  Mai-Kim Gervais¹  Alexis-Simon Cloutier¹  Atuhani Burnett² 

[1] 0000 0001 2292 3357, grid.14848.31, Centre de Recherche, Hôpital Maisonneuve-Rosemont, Université de Montréal, Montréal, QC, Canada;Banner MD Anderson Cancer Center, 80631, Greeley, CO, USA;

关键词: Colorectal cancer;    HIPEC;    Oxaliplatin;    Peritoneal carcinomatosis;   

DOI  :  10.1186/s12957-019-1618-4

来源: publisher

【 摘 要 】

BackgroundPeritoneal carcinomatosis (PC) from colorectal cancer is associated with poor prognosis. Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) has improved survival for patients with colorectal peritoneal carcinomatosis. However, standardization of HIPEC protocols, including which chemotherapeutic agent to use, is lacking in the literature. Therefore, we sought to report survival outcomes from colorectal cancer patients undergoing CRS/oxaliplatin-based HIPEC at our institution over the last 10 years.MethodsColorectal PC patients treated with CRS/oxaliplatin-based HIPEC 2004–2015 were included. Demographic, clinical, and oncologic data were abstracted from the medical record. Overall (OS) and disease-free survival (DFS) were calculated using Kaplan–Meier analysis. Univariate/multivariate Cox regression analysis was done.ResultsLaparotomy was performed in 113 patients for colorectal PC; 91 completed a curative intent CRS/HIPEC. At 3 and 5 years, OS for the CRS/HIPEC cohort was 75% and 55%, and DFS was 50% and 25%, respectively. On multivariate analysis, incremental increases in peritoneal carcinomatosis index (PCI) were associated with worse OS (p = 0.0001) and DFS (p = 0.0001). Grade III/IV complications were also associated with worse OS.ConclusionsA standardized regimen of CRS and oxaliplatin-based HIPEC for colorectal PC is effective with favorable OS and DFS and acceptable complication rates.

【 授权许可】

CC BY