Oxaliplatin-based versus irinotecan-based hyperthermic intraperitoneal chemotherapy (HIPEC) in patients with peritoneal metastasis from appendiceal and colorectal cancer: a retrospective analysis

BMC Cancer

Gabriel Glockzin³  Michael Gerken¹  Sven A Lang³  Monika Klinkhammer-Schalke¹  Pompiliu Piso²  Hans J Schlitt³ 

[1] Tumor Center Regensburg e. V., University Regensburg, Regensburg, Germany

[2] Department of Surgery, Hospital of the Order of St. John of God, Regensburg, Germany

[3] Department of Surgery, University Hospital Regensburg, 93042 Regensburg, Germany

关键词: Survival;    Morbidity;    Oxaliplatin;    Irinotecan;    HIPEC;    Peritoneal carcinomatosis;   

Others  :  1120238
DOI  :  10.1186/1471-2407-14-807

 received in 2014-04-23, accepted in 2014-10-23,  发布年份 2014

【 摘 要 】

Background

Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival results. Many different drug combinations and HIPEC regimens including bidirectional, i.e. synchronous intravenous and intraperitoneal, drug application have been used. However, there is still no standardization of the HIPEC regimen.

Methods

Between 05/2007 and 04/2010 190 patients underwent CRS and HIPEC at the University Hospital Regensburg. Thirty-two patients with peritoneal metastasis arising from colorectal or appendiceal cancer underwent complete macroscopic cytoreduction (CC-0/1) and bidirectional HIPEC and completed at least 3-year follow-up. Twenty patients received oxaliplatin-based (OX) and twelve patients received irinotecan-based HIPEC (IRI). Group-specific perioperative morbidity and 3-year survival has been determined.

Results

The grade 3/4 morbidity rate according to CTCAE v4 was 35.0% in the OX group vs. 33.3% in the IRI group (p = 1.000). There was no perioperative mortality in both groups. Median survival was 26.8 months (95% CI 15.7-33.1 months) in the IRI group and has not yet been reached in the OX group during a median follow-up of 39.4 months. Three-year survival rates were 65.0% in the OX group vs. 41.7% in the IRI group (p = 0.295).

Conclusions

The morbidity and toxicity rates of bidirectional irinotecan-based and oxaliplatin-based HIPEC are comparable. Nevertheless, in the absence of contraindications oxaliplatin-based HIPEC might be preferred due to the positive trend regarding 3-year and median survival.

【 授权许可】

   
2014 Glockzin et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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