A novel electrospun membrane based on moxifloxacin hydrochloride/poly(vinyl alcohol)/sodium alginate for antibacterial wound dressings in practical application

Drug Delivery

Hong Xie¹  Qing Wang¹  Ruoqiu Fu²  Sanjun Shi²  Zhuoheng Li²  Chenwen Li²  Caiping Yu²  Laichun Lu² 

[1] College of Pharmacy, Chongqing Medical University, Chongqing, P. R. Chin;Department of Pharmacy, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, P. R. China an;

关键词: Biodegradable polymers;    biomaterials;    electrospinning;    nanotechnology;    wound healing;   

DOI  :  10.3109/10717544.2014.918676

来源: publisher

【 摘 要 】

This study reports on the performance of sodium alginate (SA)/poly(vinyl alcohol) (PVA)/moxifloxacin hydrochloride (MH) nanofibrous membranes (NFM) capable of providing antibacterial agent delivery for wound-dressing applications. The aim of this work was to prepare antibacterial NFM with good permeability properties by employing PVA and SA as carriers. A group of 12% PVA/2% SA solutions blended in various ratios (8:2, 7:3, 6:4, 5:5 and 4:6, v/v) and containing 0.5, 1, 2 or 4 wt% MH were studied for electrospinning into nanoscale fibermats. The optimum ratio found to form smooth fibers with uniform fibrous features was 6:4. The drug release behavior of the electrospun, the antibacterial effects on Pseudomonas aeruginosa and Staphylococcus aureus and the animal wound dressing capabilities were also investigated. As much as 80% of the MH was released from the electrospun after 10 h of incubation at 37 °C. In addition, the NFM with 0.5 MH exhibited less activity, whereas those with higher concentrations of MH exhibited greater antibacterial effect. Furthermore, the MH-loaded electrospun accelerated the rate of wound dressing compared to other groups. The results of the in vitro and in vivo experiments suggest that MH/PVA/SA nanofibers might be an interesting bioactive wound dressing for clinical applications.

【 授权许可】

Unknown