Drug Delivery | |
Improvement of chemosensitivity and inhibition of migration via targeting tumor epithelial-to-mesenchymal transition cells by ADH-1-modified liposomes | |
Wenqing Li1  Kun Ma1  Zhaoming Guo1  Kun Zheng1  Yue Yuan1  Yu Tang1  Changhao Cui1  Li Wang1  Bing He2  Qiang Zhang2  | |
[1] School of Life Science and Medicine, Dalian University of Technology, Panjin, Liaoning, China;State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, Chin; | |
关键词: Chemoresistance; migration; targeting; delivery; liposomes; | |
DOI : 10.1080/10717544.2017.1417511 | |
来源: publisher | |
【 摘 要 】
How to overcome drug resistance and prevent tumor metastasis is key to the success of malignant tumor therapy. In this paper, ADH-1 peptide-modified liposomes (A-LP) have been successfully constructed for restoring chemosensitivity and suppressing cancer cell migration. With a particle size of about 90 nm, this functionalized nanocarrier was loaded with fluorescent probe or paclitaxel (PTX). Cellular uptake studies showed that A-LP facilitated the delivery of anticancer drug to tumor cells undergoing EMT. Interestingly, this nanocarrier enhanced chemosensitivity by assessing the cell activity using CCK-8 assay. Further, the results of Wound scratch assay and Transwell migration assay showed the inhibition effect of this nanocarrier on tumor cell migration. Moreover, this nanocarrier exhibited significant tumor-targeting ability and anti-tumor efficacy in vivo. Collectively, A-LP might be a novel targeted drug delivery system to enhance the efficacy of chemotherapy and prevent tumor metastasis.
【 授权许可】
CC BY
【 预 览 】
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RO202004235540652ZK.pdf | 2800KB | download |