Prevalence of dementia in the People’s Republic of China from 1985 to 2015: a systematic review and meta-regression analysis

BMC Public Health

Yangjun Zhu¹  Jun Yang²  Jun Zhang²  Xi-Li Lu²  Bo Zhang²  Wanwen Weng²  Hao Liu²  Meng-Jie Dong³ 

[1] 0000 0004 1759 700X, grid.13402.34, Department of Ultrasound, the First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, People’s Republic of China;0000 0004 1759 700X, grid.13402.34, The Department of Nuclear Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, 310003, Hangzhou, People’s Republic of China;0000 0004 1759 700X, grid.13402.34, The Department of Nuclear Medicine, the First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, 310003, Hangzhou, People’s Republic of China;Key Laboratory of Precision Diagnosis and Treatment for Hepatobiliary and Pancreatic Tumours of Zhejiang Province, 310003, Hangzhou, People’s Republic of China;

关键词: Dementia;    Alzheimer’s disease;    Vascular dementia;    China;    Prevalence;   

DOI  :  10.1186/s12889-019-6840-z

来源: publisher

【 摘 要 】

BackgroundIn China, the most populous developing country in the world, dementia represents a serious challenge. We performed a large-scale systematic review and meta-regression analysis to elucidate the prevalence of dementia and its subtypes and to identify potential factors underlying the differences between articles.MethodsA comprehensive literature search was conducted in the following databases to identify studies published up to December 2015: Cochrane Library, CBMDISK, Chongqing VIP, CNKI, PubMed and EMBASE. All statistical analyses (including subtype and meta-regression analyses) were performed with R version 3.3.3.ResultsIn total, 51 surveys were selected. The pooled prevalence rates of dementia and its main subtypes, namely, Alzheimer’s disease (AD) and vascular dementia (VAD), for the population aged 55 years and older were 4.03, 2.44 and 1.09%, respectively. The outcomes showed that the meta-regression analysis was affected by the publication year, sample size, region and diagnostic criteria.ConclusionsOur analysis provided reliable estimates of the prevalence of dementia/ AD/ VD over the past 30 years, which may be affected by education level, and diagnostic criteria. The prevalence of AD/VAD was higher in northern than in southern China, which warrants further study.

【 授权许可】

CC BY