Time to positivity of blood culture is a risk factor for clinical outcomes in Staphylococcus aureus bacteremia children: a retrospective study

BMC Infectious Diseases

Guangli Zhang¹  Zhengxiu Luo¹  Huan Ma²  Qian Yi²  Qinyuan Li²  Lili Jiang²  Fengtao Suo²  Yi Wu²  Yuanyuan Li²  Jiao Wan² 

[1]0000 0000 8653 0555, grid.203458.8, Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, 401122, Chongqing, China

[2]Key Laboratory of Pediatrics in Chongqing, Chongqing, China

[3]Department of Children’s Hospital of Chongqing Medical University of Education, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing, China

关键词: Time to positivity;    S.aureus;    Children;   

DOI  :  10.1186/s12879-019-3993-4

来源: publisher

【 摘 要 】

BackgroundStaphylococcus aureus (S. aureus) is a common cause of bacteremia, which leads to significant morbidity and mortality. We investigated the relationship between time to positivity (TTP) and clinical outcomes in children with S.aureus bacteremia in the China.MethodsA retrospective study of Staphylococcus aureus bacteremia inpatient was performed in Children’s Hospital of Chongqing Medical University in China between 29 January 2014 and 29 August 2017. TTP and clinical parameters were determined and analyzed. The receiver operating characteristic (ROC) curves were plotted for optimal cut-off selection, multivariate logistic regression tests were performed to evaluate the association between TTP and clinical outcomes.ResultsOverall, 84 cases were enrolled. We stated that in-hospital mortality is significantly higher in the early TTP (≤17 h) than in the late TTP (> 17 h) group (57.14% vs 7.14%, P = 0.000). Septic shock occurred in 57.14% of patients with early TTP and in 18.57% of patients with late TTP (P = 0.002). Detailed multivariate and statistical analysis revealed that early TTP, need for vasoactive agent were independent risk factors of in-hospital mortality; early TTP, need for vasoactive agent and APACHE II score ≥ 15 were independent risk factors of septic shock incidence in S. aureus bacteremia children.ConclusionsOverall, TTP of ≤17 h appeared to correlate with the worse outcomes for S. aureus bacteremia children. These results have important implications in the assessments and management of pediatric S. aureus bacteremia in a clinical setting.Trial registrationRetrospectively registered.

【 授权许可】

CC BY