Potential role of sympathetic activity on the pathogenesis of massive pulmonary embolism with circulatory shock in rabbits

Respiratory Research

Yuting Wang¹  Ye Gu¹  Delong Yu¹  Liqun Hu¹  Yijun Yu¹  Xiaohui Zeng¹  Wusong Zou¹ 

[1] 0000 0004 0368 7223, grid.33199.31, Department of Cardiology, Wuhan Fourth Hospital; Puai Hospital affiliated to Tongji Medical College, Huazhong University of Science and Technology, HanZheng Street 473# QiaoKou District, 430033, Wuhan, China;

关键词: Acute pulmonary embolism combined with shock;    Pulmonary arterial hypertension;    Sympathetic activity;    Sodium nitroprusside;    Diltiazem;   

DOI  :  10.1186/s12931-019-1069-z

来源: publisher

【 摘 要 】

BackgroundWe recently showed that intravenous sodium nitroprusside treatment (SNP) could relieve the pulmonary vasospasm of pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions in a rabbit massive pulmonary embolism (MPE) model associated with shock. The present study explored the potential role of cardiopulmonary sympathetic activity on the pathogenesis and the impact of vasodilators on cardiopulmonary sympathetic activity in this model.MethodsRabbits were randomly divided into sham operation group (S group, n = 8), model group (M, equal volume of saline intravenously, n = 11), SNP group (3.5 μg/kg/min intravenously, n = 10) and diltiazem group (DLZ, 6.0 μg/kg/min intravenously, n = 10).ResultsMPE resulted in reduced mean arterial pressure and increased mean pulmonary arterial pressure as well as reduced PaO2 in the M, SNP and DLZ groups. Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group. Both SNP and DLZ decreased mean pulmonary arterial pressure, reversed shock status, downregulated the expression of TH, NPY and ET-1, and increased NO levels in PE and non-PE regions.ConclusionPresent results indicate that upregulation of the sympathetic medium transmitters TH and NPY in whole lung tissues serves one of the pathological features of MPE. The vasodilators SNP and DLZ could relieve pulmonary vasospasm in both embolization and non-embolization regions and reverse circulatory shock, thereby indirectly downregulating the sympathetic activation of the whole lung tissues and breaking a vicious cycle related to sympathetic activation in this model.

【 授权许可】

CC BY