The protective role of jervine against radiation-induced gastrointestinal toxicity

Journal of Enzyme Inhibition and Medicinal Chemistry

Selvinaz Yakan¹  Ozkan Ozden²  Onur Atakisi³  Ahmet Cakir⁴  Kivilcim Eren Erdogan⁵  Canan Gulmez⁶  Fundagul Andic⁷  Yusuf Kenan Daglioglu⁸  Tuba Aydin⁹ 

[1] Animal Health Department, Agri Ibrahim Cecen University Eleskirt Celal Oruc School of Animal Production, Agri, Turkey;Department of Bioengineering, Faculty of Engineering and Architecture, Kafkas University, Kars, Turkey;Department of Chemistry, Faculty of Science and Letter, Kafkas University, Kars, Turkey;Department of Chemistry, Faculty of Science and Literature, Kilis 7 Aralık University, Kilis, Turke;Department of Pathology, Faculty of Medicine, Cukurova University, Adana, Turkey;Department of Pharmacy Services, Tuzluca Vocational School, Igdir University, Igdir, Turkey;Department of Radiation Oncology, Faculty of Medicine, Cukurova University, Adana, Turkey;Experimental Medicine Research Center, Cukurova University, Adana, Turkey;Faculty of Pharmacy, Agri Ibrahim Cecen University, Agri, Turkey;

关键词: Radiotherapy;    jervine;    pyruvate dehydrogenase (PDH);   

DOI  :  10.1080/14756366.2019.1586681

来源: publisher

【 摘 要 】

In this study, we investigated whether jervine (J) could prevent gastrointestinal (GI) side effects of abdominopelvic radiotherapy (RT) in Wistar-Albino female rats. Rats were divided into five groups: control (C), J only (J), J administered at 5 mg/kg/days for 7 days, RT only (RT), J before RT (J + RT), J administered for seven days before RT, J both before and after RT (J + RT + J), and J administered for 7 days before RT and after RT for 3 days. The weights of rats were measured on the 1st, 7th, and 10th days of the study. Rats were sacrificed to obtain tissues from the liver and intestine, which was followed by taking blood samples intracardially. In addition, the tissues were stained with pyruvate dehydrogenase (PDH) immunohistochemically. In our study, J supplementation markedly reduced weight loss, and histopathological, immunohistochemical, biochemical results suggest that J had a protective effect on GI toxicity following RT.

【 授权许可】

CC BY