Reduction and Preparation of a Phthalimide Derivative from a Furo-heliangolide

Molecules

Gil Valdo José Da Silva¹  Vladimir Constantino Gomes Heleno¹ 

[1] Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Av. Bandeirantes 3900, 14040-901 – Ribeirão Preto – SP, Brazil

关键词: Furo-heliangolides;    Goyazensolide;    Reduction;    Phthalimide derivative;    Wilkinson’s catalyst;   

DOI  :  10.3390/50600908

来源: mdpi

【 摘 要 】

Goyazensolide, a biologically active natural product classified as a furoheliangolide, was transformed in a phthalimide derivative that showed an enhanced biological activity against Tripanosoma cruzi. The complex natural product was also reduced with high stereoselectivity by hydrogen/Wilkinson’s catalyst; an epimer of this product was obtained in the reduction with hydrogen/Pd-C.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.