Ligation of the spermatic cord in dogs with a self-locking device of a resorbable polyglycolic based co-polymer – feasibility and long-term follow-up study

BMC Research Notes

Anne-Sofie Lagerstedt²  Niklas Borg¹  Kerstin Hansson²  Fredrik Södersten³  Jessica Ingman⁴  Odd V Höglund² 

[1] Radi Medical Systems, Palmbladsgatan 10, SE-754 50 Uppsala, Sweden;Department of Clinical Sciences, Swedish University of Agricultural Sciences, Box 7054, SE-750 07 Uppsala, Sweden;Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Box 7028, SE-750 07 Uppsala, Sweden;University Animal Hospital, Swedish University of Agricultural Sciences, Box 7040, SE-750 07 Uppsala, Sweden

关键词: Refinement;    Reduction;    Replacement;    Ultrasonography;    Castration;    Block co-polymer;    Trimethylene carbonate;    Glycolide;    Bioabsorbable;    Resorbable medical device;   

Others  :  1123210
DOI  :  10.1186/1756-0500-7-825

 received in 2014-11-04, accepted in 2014-11-05,  发布年份 2014

【 摘 要 】

Background

New surgical techniques are developed to enable a quicker, easier and safer surgery with reduced risk of complications and shortened time needed for recovery. A resorbable device, a self-locking loop, was designed for surgical ligation. The objective of this pilot study was to investigate the feasibility of ligating the spermatic cord with the device, its biocompatibility and long-term resorption in dogs.

Results

The device was made of a block co-polymer (glycolide and trimethylene carbonate), manufactured by injection moulding and consisted of a flexible band running through a case with a locking mechanism. Ten devices were tested for ligation of the spermatic cords in five dogs admitted for routine neutering. The dogs were monitored by physical examination and ultrasonography of the site of ligation, area of spermatic cord and medial iliac lymph nodes regularly until no hyperechoic remnants of the device or acoustic shadowing or local tissue reactions were observed. Haemostasis of the spermatic cords was achieved with the devices. On ultrasonography the devices were seen as hyperechoic structures for 2 months after neutering causing acoustic shadowing for 1 month. The dogs were monitored for 3 – 5 months after surgery. Gradual decrease in echogenicity and final disappearance of the hyperechoic structures suggested resorption. Macroscopic and histological post mortem examinations were performed in one dog at 3 months after surgery. Post mortem examination showed a tissue reaction of a suture granuloma that was restricted in extent at site of the device.

Conclusions

The results of this pilot study suggest biocompatibility and indicate that ligation of the spermatic cord is feasible with the device.

【 授权许可】

   
2014 Höglund et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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