Molecules | |
Benzamidomethylation with (Benzamidomethyl)triethylammonium Chloride. 2. A Simple Method for Benzamidomethylation of Thiols, Amines and Carboxylic Acids | |
Emil Popovski1  Ljiljana Klisarova1  | |
[1] 1Institute of Chemistry, Faculty of Natural Sciences & Mathematics, Sts. Cyril and Methodius University, PO Box 162, 1000 Skopje, Macedonia 2Faculty of Pharmacy, Sts. Cyril and Methodius University, 1000 Skopje, Macedonia 3Rudjer Boskovic Institute, Bijenicka 54, HR-10001, Zagreb, Croatia | |
关键词: Benzamidomethylation; thiols; carboxylic acids; amines; | |
DOI : 10.3390/50700927 | |
来源: mdpi | |
【 摘 要 】
Thiols and amines were benzamidomethylated in water solution at room temperature with (benzamidomethyl)triethylammonium chloride (1) in the presence of a small quantity of triethylamine (pH>9). Benzamidomethyl thioethers (3a-d) and (benzamidomethyl) amines or di(benzamidomethyl)amines (5) were obtained in high yields (>90%) as well as S(CH2NHBz)2 in a reaction of 1 with Na2S. Benzamidomethyl esters RCOOCH2NHBz were obtained (60-75%) in reactions of carboxylic acids with 1 in chloroform or dioxane.
【 授权许可】
CC BY
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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