Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives

Molecules

Afaf H. El-masry¹  H. H. Fahmy¹ 

[1] Therapeutical Chemistry Department. National Research Centre, Dokki, Cairo, Egypt

关键词: Methylbenzimidazole;    oxadiazole;    thioglycolic;    thiolactic;    triazole;    pyrazole;    antimicrobial;   

DOI  :  10.3390/51201429

来源: mdpi

【 摘 要 】

Reaction of 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide (1) with CS₂/KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.