Ion Selective PVC Membrane Electrode for the Determination of Methacycline Hydrochloride in Pharmaceutical Formulation

Sensors

Hassan Y. Aboul-Enein¹  Xian Xiang Sun² 

[1] Pharmaceutical Analysis Laboratory Biological and Medical Research Department, MBC-03-65, King Faisal Specialist Hospital & Research Center, P.O. Box 3354, Riyadh 11211, Saudi Arabia;Department of Chemical Engineering, Jiangsu Institute of Petrochemical Technology, Changzhou 213016, Peoples Republic of China

关键词: Ion-selective electrode;    Potentiometry;    Methacycline;    Drug analysis;   

DOI  :  10.3390/s21000424

来源: mdpi

【 摘 要 】

A plastic membrane electrode for the determination of methacycline hydrochloride was fabricated based on the use of methacycline-tetraphenylborate as the electroactive substance, and dioctylphtalate as the plasticizing agent. It was found that the potential responses of the electrode were influenced by pH of the tested solution when pH>3. Under the condition of pH 2.6, the linear response range, slope (25°C) and detection limit obtained were  3.0×10^-2~6.0×10^-6M, 52.9mv per decade and 3.4×10^-6M ,respectively. The response time of the electrodes was <15 seconds. The values of recovery obtained were 99.2~101.2%. The electrode was successfully applied to determination of methacycline hydrochloride in tablet by direct potentiometric method. The result obtained with the electrode was in good agreement with the value obtained by using the official method (high-performance liquid chromatography).

【 授权许可】

Unknown   
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