C- versus O-Arylation of an Enol-Lactone Using Potassium tert-butoxide

International Journal of Molecular Sciences

Sanae Ibrahimi¹  Gilles Sauvé¹ 

[1] ¹INRS-Institut Armand-Frappier, 531 Boul. des Prairies, Laval, Québec, Canada ²Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Université Mohamed V, Rabat, Marocco

关键词: Arylation;    Enol-lactone;    Potassium tert-butoxide;   

DOI  :  10.3390/i4060371

来源: mdpi

【 摘 要 】

The use of potassium tert-butoxide as the base in arylation reactions of an enollactone with a series of benzyl halides was explored. Our work demonstrates that the ratio of C-arylation to O-arylation varies with the substitution pattern of the aryl halide.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.