Microwave-Assisted Amination of a Chloropurine Derivative in the Synthesis of Acyclic Nucleoside Analogues

Molecules

Andreas Lanver¹ 

[1] id="af1-molecules-10-01169">Institut für Organische Chemie, Universität zu Köln, Greinstrasse 4, 50939 Köln, Germany Fax: [phone]

关键词: Microwave;    nucleophilic aromatic substitution;    nucleosides;   

DOI  :  10.3390/10020508

来源: mdpi

【 摘 要 】

An efficient protocol for the amination of 6-chloropurine derivatives through nucleophilic aromatic substitution under microwave irradiation was developed and applied to the synthesis in two steps of a series of new acyclic nucleosides (acyclovir analogues) starting from commercially available compounds.

【 授权许可】

Unknown   
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