A Simple Synthetic Route to Methyl 3-Fluoropyridine-4-carboxylate by Nucleophilic Aromatic Substitution

Molecules

Freddy Tjosaas¹ 

[1] Department of Chemistry, Norwegian University of Science and Technology, NTNU N-7491 Trondheim, Norway. ^† E-mail:

关键词: Methyl 3-fluoropyridine-4-carboxylate;    methyl 3-nitropyridine-4-carboxylate;    fluoride anion;    nucleophilic aromatic substitution;   

DOI  :  10.3390/11020130

来源: mdpi

【 摘 要 】

The nitro group of methyl 3-nitropyridine-4-carboxylate (1) has successfully been replaced by fluoride anion via nucleophilic aromatic substitution to give the 3-fluoro-pyridine-4-carboxylate 2.

【 授权许可】

Unknown   
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