Cyclization of Free Radicals at the C-7 Position of Ethyl Indole–2-carboxylate Derivatives: an Entry to a New Class of Duocarmycin Analogues

Molecules

Naim H. Al-Said¹  Khaled Q. Shawakfeh² 

[1] id="af1-molecules-10-01446">Department of Applied Chemical Science, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan.  Fax: [phone]

关键词: Duocarmycin;    free-radicals;    intramolecular cyclization;    indole;    pyrroloquinoline;   

DOI  :  10.3390/10121446

来源: mdpi

【 摘 要 】

Aryl free-radicals generated at the C-7 position of ethyl indole-2-carboxylates bearing N-allyl and propargylic groups triggered intramolecular cyclizations to furnish a new class of Duocarmycin analogues, formal ethyl pyrrolo[3,2,1-ij]quinoline-2-carboxylate derivatives, through the less favorable 6-endo-trig cyclization mode.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).