Synthesis and Antidepressant Evaluation of Three para-Benzoquinone Mono-oximes and Their Oxy Derivatives

Molecules

Damião Pergentino de Sousa¹  Renata Rabelo Schefer²  Ursula Brocksom² 

[1] id="af1-molecules-11-00148">Química Bio-Orgânica, Departamento de Química, Universidade Federal de São Carlos, Caixa Postal 676, 13565-905 São Carlos, SP, Braz

关键词: Oximes;    para-benzoquinones;    antidepressant activity;   

DOI  :  10.3390/11020148

来源: mdpi

【 摘 要 】

A series of three para-benzoquinone mono-oximes and four oxy-derivatives were prepared and tested for their antidepressant properties. The (4E) oxime of 2-isopropyl-5-methyl-para-benzoquinone (4) and the corresponding 2-diethylamino-ethyl derivative (10) present antidepressant activities and were slightly more potent than the reference standard.

【 授权许可】

Unknown   
© 2006 by MDPI (http://www.mdpi.org).