Isosakuranetin-5-O-rutinoside: A New Flavanone with Antidepressant Activity Isolated from Salvia elegans Vahl

Molecules

Manáses González-Cortazar²  Ana Mar໚ Maldonado-Abarca²  Enrique Jiménez-Ferrer²  Silvia Marquina¹  Elsa Ventura-Zapata³  Alejandro Zamilpa²  Jaime Tortoriello² 

[1] Chemical Research Center, Universidad Autónoma del Edo. de Morelos (UAEM), Av. Universidad 1001, Col. Chamilpa 62210, Cuernavaca, Morelos, Mexico; E-Mail:;Southern Biomedical Research Center, Mexican Institute of Social Security, Argentina 1, Centro 62790, Xochitepec, Morelos, Mexico; E-Mails:;Center Biotic Products, Instituto Politécnico Nacional (IPN), 62761 Yautepec, Morelos, Mexico; E-Mail:

关键词: Salvia elegans;    flavanone;    rutinoside;    isosakuranetin;    NMR;    ursolic acid;    antidepressant activity;   

DOI  :  10.3390/molecules181113260

来源: mdpi

【 摘 要 】

Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as ¹H- and ¹³C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.