Isolation and Biological Activity of New and Known Diterpenoids From Sideritis stricta Boiss. & Heldr

Molecules

关键词: Kaurene;    Diterpenoids;    Sideritis stricta;    Lamiaceae;    Antibacterial Activity;   

DOI  :  10.3390/11040257

来源: mdpi

【 摘 要 】

Nine known and one new ent-kaurene diterpenoid were isolated from the acetone extract of Sideritis stricta Boiss & Heldr. The new compound, identified as ent-1β-hydroxy-7α-acetyl-15β,16β-epoxykaurane (1) by IR, 1D and 2D NMR techniques and mass spectra, was isolated along with sideroxol (2), 7-acetyl sideroxol (3), 7-epicandicandiol (4), linearol (5), ent-7α,15β,18-trihydroxy-kaur-16-ene (6), ent-7α-acetyl,15,18-dihydroxy-kaur-16-ene (7), foliol (8), sideridiol (9) and siderol (10). The antibacterial and antifungal activities of these compounds and the whole crude acetone extract were evaluated against E. coli, S. aureus, K. pneumeonia and C. albicans.

【 授权许可】

Unknown   
© 2006 by MDPI (http://www.mdpi.org).