A Structure-Activity Study of Antibacterial Diterpenoids

Molecules

Alejandro Urzྪ¹   Marcos C. Rezende²  Carolina Mascayano² 

[1] id="af1-molecules-13-00882">Facultad de Química y Biología, Casilla 40, Correo 33, Universidad de Santiago de Chile, Santiago, Chi

关键词: Diterpenoids;    antibacterial activity;    structural requirements;    phospholipid bilayer;    docking;   

DOI  :  10.3390/molecules13040822

来源: mdpi

【 摘 要 】

An analysis of the antibacterial activities of 15 terpenoids, eleven of which were previously described by us and four were extracted from the literature, suggested two structural requirements for activity of these and related compounds: a hydrophobic moiety, consisting of a substituted decalin skeleton, and a hydrophilic region possessing one hydrogen-bond-donor group. These structural requirements are responsible for an optimal insertion of these and related compounds into cell membranes, as suggested by the results of docking some of these compounds into a model phospholipid bilayer.

【 授权许可】

Unknown   
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