期刊论文详细信息
Molecules | |
A Novel Synthesis of |
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Guiping Ouyang2  Baoan Song1  Huiping Zhang2  Song Yang2  Linhong Jin2  Qianzhu Li2  | |
[1] id="af1-molecules-10-01351">Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China. Tel.: (+86) 851 362 0521, Fax: (+86) 851 362 221 | |
关键词: 2-Cyanoacrylate; aromatic amine; aminopyridine; microwave irradiation; | |
DOI : 10.3390/10101351 | |
来源: mdpi | |
【 摘 要 】
A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.
【 授权许可】
Unknown
© 2005 by MDPI (http://www.mdpi.org).
【 预 览 】
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RO202003190059862ZK.pdf | 125KB | download |