A Novel Synthesis of (E)-3-Methylthio-3-Substituted Arylamino- 2-Cyanoacrylates under Microwave Irradiation

Molecules

Guiping Ouyang²  Baoan Song¹  Huiping Zhang²  Song Yang²  Linhong Jin²  Qianzhu Li² 

[1] id="af1-molecules-10-01351">Research and Development Center for Fine Chemicals, Key Laboratory of Green Pesticide and Agriculture Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, P. R. China. Tel.: [phone], Fax: [phone]

关键词: 2-Cyanoacrylate;    aromatic amine;    aminopyridine;    microwave irradiation;   

DOI  :  10.3390/10101351

来源: mdpi

【 摘 要 】

A facile synthesis of 3-methylthio-3-arylamino-2-cyanoacrylates from 3,3-dimethylthioacrylate and aromatic amines or amino pyridines has been achieved in moderate to high yields (64.0% ~ 93.5%) in 30 minutes at 50°C under microwave irradiation. This method is very simple and the reaction conditions are mild, environmentally friendly and more importantly, quick. In the 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) test, some of the title compounds were found to possess good antiproliferation activity towards PC3 cells.

【 授权许可】

Unknown   
© 2005 by MDPI (http://www.mdpi.org).