The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Molecules

Nagatoshi Nishiwaki¹  Mina Tamura¹  Kazushige Hori¹  Yasuo Tohda¹ 

[1] Department of Chemistry, Osaka Kyoiku University, Asahigaoka, Kashiwara, Osaka 582-8582, Japan

关键词: Nitropyrimidinone;    ring transformation;    pyridone;    pyrimidine;    aminopyridine;   

DOI  :  10.3390/80600500

来源: mdpi

【 摘 要 】

3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4,5-disubstituted pyrimidines and functionalized 4-aminopyridines. It also behaves like α-nitro-formylacetic acid to give 5,6-disubstituted 3-nitro-2-pyridones.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.