The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors

Marine Drugs

Susan Wonnacott¹ 

[1] Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, United Kingdom, E-mail:

关键词: anatoxin-a;    homoanatoxin;    UB165;    pinnamine;    homotropane;    nicotinic acetylcholine receptor;    pharmacophore;   

DOI  :  10.3390/md403228

来源: mdpi

【 摘 要 】

This chapter covers the chemistry and nicotinic pharmacology of naturally occurring homotropane alkaloids, with an emphasis of anatoxin-a. In addition to anatoxin-a, homoanatoxin and pinnamine, as well as the major classes of synthetic derivatives of anatoxin-a including UB-165, are discussed.

【 授权许可】

Unknown   
© 2006 by MDPI