An Improved NMR Study of Liposomes Using 1-Palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine as Model

Molecules

Oscar Cruciani¹  Luisa Mannina¹  Anatoli P. Sobolev¹  Cesare Cametti¹ 

[1] ¹Istituto di Metodologie Chimiche, CNR, 00016 Monterotondo Stazione, Roma, Italy ²Dipartimento S.T.A.A.M, Università degli Studi del Molise, 86100 Campobasso, Italy ³Dipartimento di Fisica, Università di Roma "La Sapienza", piazz. A. Moro, 2, 00185 Roma, Italy and Istituto Nazionale per la Fisica della Materia (INFM), Unità di Roma1, Roma, Italy

关键词: Liposomes;    unilamellar vesicles;    multilamellar vesicles;    NMR;    HR-MAS;    dynamic light scattering;   

DOI  :  10.3390/11050334

来源: mdpi

【 摘 要 】

In this paper we report a comparative characterization of Small UnilamellarVesicles (SUVs), Large Unilamellar Vesicles (LUVs) and Multilamellar Vesicles (MLVs)prepared from 1-palmitoyl-2-oleoyl-sn-glycero-3-phospatidylcholine (POPC), carried outusing two NMR techniques, namely High Resolution NMR in solution and HighResolution–Magic Angle Spinning (HR-MAS). The size and size distributions of thesevesicles were investigated using the dynamic light scattering technique. An improvedassignment of the ¹H-NMR spectrum of MLVs is also reported.

【 授权许可】

CC BY   
This is an open access article distributed under the Creative Commons Attribution License (CC BY) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.