First Synthesis of 3-Acetyl-2-aminothiophenes Using the Gewald Reaction

Molecules

Gernot A. Eller¹ 

关键词: Gewald reaction;    Thiophene synthesis;    Cyclization;    Condensation;   

DOI  :  10.3390/11050371

来源: mdpi

【 摘 要 】

Novel 3-acetyl-2-aminothiophenes were prepared from cyanoacetone and 1,4‑dithianyl-2,5‑diols using a modified Gewald reaction. The syntheses of the corresponding acetamides, as well as that of 3‑acetyl-2‑amino-5‑nitrothiophene – an interesting building-block for thiophene azo dyes – are reported. Detailed spectroscopic investigations (¹H‑NMR, ¹³C-NMR, MS, IR) of the obtained compounds are presented.

【 授权许可】

Unknown   
© 2006 by MDPI (http://www.mdpi.org).