Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate

Molecules

Andrew J. Walsh¹  Michael L. Davis¹ 

[1] id="af1-molecules-11-00486">School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK Tel.: [phone], Fax. [phone]

关键词: CPG;    conjugate;    metronidazole;    oligonucleotide;    phosphoramidite;    solid phase;   

DOI  :  10.3390/11060486

来源: mdpi

【 摘 要 】

Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% Et₃N in pyridine, then conc. NH₃ (aq) at rt for 30 min) whereas standard conditions (conc. NH₃ (aq) at 55 °C for 16 h) cleaved the drug.

【 授权许可】

Unknown   
© 2006 by MDPI (http://www.mdpi.org).