期刊论文详细信息
Molecules | |
Solid Phase Synthesis of a Metronidazole Oligonucleotide Conjugate | |
Andrew J. Walsh1  Michael L. Davis1  | |
[1] id="af1-molecules-11-00486">School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, B4 7ET, UK Tel.: +44 121 204 3940, Fax. +44 121 359 07 | |
关键词: CPG; conjugate; metronidazole; oligonucleotide; phosphoramidite; solid phase; | |
DOI : 10.3390/11060486 | |
来源: mdpi | |
【 摘 要 】
Direct, solid phase synthesis of an oligonucleotide conjugate of the antibiotic drug metronidazole was accomplished by the phosphoramidite method. Removal of protecting groups and cleavage from the controlled pore glass (CPG) solid support was successful using mild conditions (20% Et3N in pyridine, then conc. NH3 (aq) at rt for 30 min) whereas standard conditions (conc. NH3 (aq) at 55 °C for 16 h) cleaved the drug.
【 授权许可】
Unknown
© 2006 by MDPI (http://www.mdpi.org).
【 预 览 】
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RO202003190059611ZK.pdf | 75KB | download |