Cytotoxicity of Two Triterpenoids from Nigella glandulifera

Molecules

Ze Tian¹  Yu-Ming Liu¹  Si-Bao Chen¹  Jun-Shan Yang¹  Pei-Gen Xiao¹  Liao Wang² 

[1] Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100094, P.R. China;College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, P.R. China

关键词: Nigella glandulifera;    oleanane type saponins;    cytotoxicity;    HepG2;    apoptosis;   

DOI  :  10.3390/11090693

来源: mdpi

【 摘 要 】

During an investigation of antitumor substances from Nigella glandulifera Freyn et Sint. (Ranunculaceae) the cytotoxicity of two oleanane triterpene saponins isolated from the seeds of this species, kalopanaxsaponins A and I, was evaluated against HepG2, drug resistant HepG2 (R-HepG2) (two hepatocyte cell lines) and primary cultured normal mouse hepatocytes. Evident cytotoxic activities were observed. Morphological observations and cell cycle analysis suggest that these compounds inhibit the proliferation of hepatoma by inducing apoptosis and consequently kalopanaxsaponins A and I may be potential therapeutic agents for the treatment of parental and drug resistant hepatoma.

【 授权许可】

Unknown   
© 2006 by MDPI (http:www.mdpi.org).