Symmetrically and Unsymmetrically BridgedMethylenebis(allopurinols): Synthesis of Dimeric PotentialAnti-Gout Drugs

Molecules

Helmut Rosemeyer¹  Martina Anders¹ 

[1] Organische Chemie I – Bioorganische Chemie, Institut für Chemie, Fachbereich Biologie/Chemie, Universität Osnabrück, Barbarastr. 7, D-49069 Osnabrück, Germany

关键词: Allopurinol;    dimethylsulfoxide;    dimeric drugs;   

DOI  :  10.3390/12030563

来源: mdpi

【 摘 要 】

Liquid-liquid phase transfer alkylation of 4-methoxy-pyrazolo[3,4-d]-pyrimidine (1a) with a dichloromethane/dibromomethane mixture (3:1, v/v) gave the regioisomeric methylenebis(heterocycles) 3a–5a. These were converted by dilute aqueous sodium hydroxide containing dimethylsulfoxide (DMSO) at concentrations between 0 and 60 vol-% into the methylenebis(allopurinols) 3b–5b by nucleophilic S_NAr reactions at C(4). The effect of DMSO on the reaction kinetics was investigated.

【 授权许可】

Unknown   
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