Complexes of 3dn Metal Ions with Thiosemicarbazones: Synthesis and Antimicrobial Activity

Molecules

Tudor Rosu³  Aurelian Gulea¹  Anca Nicolae² 

[1] Faculty of Chemistry, Inorganic Chemistry Department, USM-R. Moldavia; E-mail:;Organic Chemistry Department, University of Bucharest, 90 – 92 Panduri Bd., sector 4, Bucharest, Romania; E-mail:;Inorganic Chemistry Department, University of Bucharest, 23 Dumbrava Rosie Street, sector 2, Bucharest, Romania

关键词: Thiosemicarbazone complexes;    copper complexes;    thiosemicarbazones;    antimicrobial activity;   

DOI  :  10.3390/12040782

来源: mdpi

【 摘 要 】

The chelating behavior of the thiosemicarbazone derivatives of 2-hydroxy-8-R-tricyclo[7.3.1.0.^2,7]tridecane-13-one (where R = H, CH₃, C₆H₅) towards Co(II), Ni(II) and Cu(II) has been investigated by elemental analysis, molar conductivity measurements, UV-VIS, IR, ESR spectroscopy and thermal studies. It was deduced from the experiments performed that the ligands coordinate to metal ions in different ways – neutral bidentate or mononegative bidentate – depending on the nature of R. Also, if metal acetates are used instead of metal chlorides, the ligands coordinate in a mononegative bidentate fashion, regardless of the nature of R or the thiosemicarbazone type ligand.  The antimicrobial activity of the ligands and of the complexes towards samples of Acinetobacter boumanii, Klebsiella pneumoniae, Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa was determined.

【 授权许可】

Unknown   
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