Synthesis and Characterization of Some New Cu(II), Ni(II) and Zn(II) Complexes with Salicylidene Thiosemicarbazones: Antibacterial, Antifungal and in Vitro Antileukemia Activity

Molecules

Elena Pahontu⁴  Valeriu Fala¹  Aurelian Gulea³  Donald Poirier²  Victor Tapcov³ 

[1] Dental Education Department, Moldova State University of Medicine and Pharmacy “N. Testemitsanu” Chisinau, Republic of Moldova;Laboratory of Medicinal Chemistry, CHUQ (CHUL)- Research Center and Université Laval, 2705 Boulevard Laurier, Québec City, QC G1V 4G2 Canada;Coordination Chemistry Department, Moldova State University, 60 Mateevici Street, 2009 Chisinau, Republic of Moldova;Inorganic Chemistry Department, Faculty of Pharmacy, University of Medicine and Pharmacy “Carol Davila”, 6 Traian Vuia Street, 020956 Bucharest, Romania

关键词: copper;    nickel;    zinc complexes;    thiosemicarbazones;    antimicrobial activity;    antileukemia;   

DOI  :  10.3390/molecules18088812

来源: mdpi

【 摘 要 】

Thirty two new Cu(II), Ni(II) and Zn(II) complexes (1–32) with salicylidene thiosemicarbazones (H₂L¹–H₂L¹⁰) were synthesized. Salicylidene thiosemicarbazones, of general formula (X)N-NH-C(S)-NH(Y), were prepared through the condensation reaction of 2-hydroxybenzaldehyde and its derivatives (X) with thiosemicarbazide or 4-phenylthiosemicarbazide (Y = H, C₆H₅). The characterization of the new formed compounds was done by ¹H-NMR, ¹³C-NMR, IR spectroscopy, elemental analysis, magnetochemical, thermoanalytical and molar conductance measurements. In addition, the structure of the complex 5 has been determined by X-ray diffraction method. All ligands and metal complexes were tested as inhibitors of human leukemia (HL-60) cells growth and antibacterial and antifungal activities.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.