Cytotoxic Triterpenoid Saponins from the Roots of Platycodon grandiflorum

Molecules

Lin Zhang¹  Zhen-Huan Liu¹ 

[1] Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China; Tel: [phone]; Fax: [phone]; E-mail

关键词: Platycodon grandiflorum;    Triterpenoid saponins;    cytotoxic activity;   

DOI  :  10.3390/12040832

来源: mdpi

【 摘 要 】

Bioguided fractionation of the ethanol extracts obtained from Platycodon grandiflorum roots led to isolation of two new triterpenoid saponins, characterized as 3-O-β-D-glucopyranosyl-2β,12α,16α,23,24-pentahydroxyoleanane-28(13)-lactone (1) and 3-O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-2β,12α,16α,23α-tetrahydroxyoleanane-28(13)- lactone (2) by 1D- and 2D-NMR and MS techniques, as well as chemical means. Both compounds showed cytotoxic activity against human ECA-109 cells.

【 授权许可】

Unknown   
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