期刊论文详细信息
International Journal of Molecular Sciences
UVB-Protective Effects of Isoflavone Extracts from Soybean Cake in Human Keratinocytes
Han-Sun Chiang2  Wen-Bin Wu2  Jia-You Fang1  Bing-Huei Chen4  Tsai-Hua Kao4  Ying-Ting Chen2  Chieh-Chen Huang3 
[1] Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan;School of Medicine, Fu-Jen Catholic University, Taipei Hsien, Taiwan;Department of Dermatology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan;Department of Nutrition and Food Sciences, Fu-Jen Catholic University, Taipei Hsien, Taiwan
关键词: isoflavone;    keratinocyte;    UVB;   
DOI  :  10.3390/i8070651
来源: mdpi
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【 摘 要 】

It has been shown by chromatography that aglycone, glucoside, acetylglucoside and malonylglucoside isoflavone extracts prepared from soybean cake showed better antioxidant activities than isoflavone standards. Consequently, the aim of this study was to evaluate the protective effects of these isoflavone extracts against ultraviolet B (UVB)-induced keratinocyte damage. Our results demonstrated that these soybean cake isoflavone extracts could inhibit UVB-induced keratinocyte death. Moreover, they could inhibit UVB-induced intracellular release of hydrogen peroxide (H2O2) Furthermore, these isoflavone extracts differentially inhibited UVB-induced MAPK phosphorylation. The ERK1/2 and p38 phosphorylation was not inhibited by all tested isoflavone extracts, whereas JNK phosphorylation was inhibited by group I to group III isoflavone extracts. Since these isoflavone extracts are relative stable and easily obtained than the isoflavone standards, we suggest that soybean cake may be a useful potential source for developing effective skin care agents in against photoaging.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org)

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