The Anti-apoptosis Effects of Daidzein in the Brain of D-Galactose Treated Mice

Molecules

Zhen Mao²  Yuan-lin Zheng²  Yan-qiu Zhang¹  Bao-ping Han²  Xiao-wan Zhu²  Qing Chang² 

[1] School of Environment Science and Spatial Informatics, China University of Mining and Technology, Xuzhou 221008, Jiangsu Province, P. R. China;Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, School of Life Science, Xuzhou Normal University, Xuzhou 221116, Jiangsu Province, P. R. China; E-mails:

关键词: Daidzein;    apoptosis;    caspase 3;    bcl-2;    bax;   

DOI  :  10.3390/12071455

来源: mdpi

【 摘 要 】

The purpose of this study was to explore the neuroprotective effects of daidzein on the apoptotic pathway in the hippocampus and cortex of D-galactose treated mice. For this purpose we have examined the expression of bcl-2 mRNA, bax mRNA and caspase-3 in the hippocampus and cortex of D-galactose-treated mice after fed with 10 or 5 mg/kg of daidzein. The results of in situ hybridization experiments indicate that daidzein could help increase the transcriptions of bcl-2 and decrease the transcriptions of bax in those brain regions of D-galactose-treated mice. Furthermore, immunohistochemical studies showed that daidzein could reduce the expression of caspase-3 in both brain regions. These results suggest that daidzein in soybean can inhibit the D-gal induced apoptosis via Bcl-2/Bax apoptotic pathway and be a potential medical candidate for neurodegeneration therapy.

【 授权许可】

Unknown   
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