Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives

Molecules

Aliasghar Jarrahpour¹  Dariush Khalili¹  Erik De Clercq³  Chanaz Salmi² 

[1]Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

[2]Laboratoire SESNAB, Faculté de St Jérôme, Case 342, Université Paul Cézanne, Av. Escadrille Normandie Niémen, 13397 Marseille cedex 20, France

[3]Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

关键词: Isatin;    bis-Schiff base;    antibacterial;    antiviral;    antifungal;   

DOI  :  10.3390/12081720

来源: mdpi

【 摘 要 】

Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The chemical structures of the products were confirmed by ¹H- and ¹³C-NMR, IR and mass spectral data. The compounds were screened for antiviral activity against a panel of DNA and RNA viruses. Minimum cytotoxic and minimum virus-inhibitory concentrations of these compounds were determined. Compounds 3c and 3i were the most cytotoxic in HEL cells. These newly synthesized bis-Schiff bases were also tested for their antibacterial and antifungal activities. They did not display activity against S. cerevisiae (ATCC 28383) or C. albicans (CIP 1180-79).

【 授权许可】

Unknown   
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