Hyperbranched Molecular Structures with Potential Antiviral Activity: Derivatives of 5,6-Dihydroxyindole-2-Carboxylic Acid

Molecules

Mario Sechi²  Fabio Casu²  Ilaria Campesi²  Stefano Fiori¹ 

[1] 2 Dipartimento di Chimica, Università di Sassari and local INSTM Research Unit, Via Vienna 2, 07100 Sassari, Italy; E-mail:;1 Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, Via Muroni 23/A, 07100 Sassari, Italy; E-mail:

关键词: Hyperbranched polymers;    AB₂ monomers;    DHICA;    HIV-1;    antiviral agents;   

DOI  :  10.3390/11120968

来源: mdpi

【 摘 要 】

In the search of new HIV-1 integrase (IN) inhibitors, we synthesized a series of multimeric 5,6-dihydroxyindole-2-carboxylic acid (DHICA) derivatives. Preliminary results indicate that hyperbranched architectures could represent a peculiar molecular requisite for the development of new antiviral lead compounds.

【 授权许可】

Unknown   
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