Tyrosinase and related proteins in mammalian pigmentation

FEBS Letters

Beermann, Friedrich²  del Marmol, Véronique¹ 

[1] LOCE, Institut J. Bordet, Université Libre de Bruxelles, rue Héger-Bordet 1, 1000 Bruxelles, Belgium;Swiss Institute for Experimental Cancer Research (ISREC), Chemin des Boveresses 155, 1066 Epalinges, Switzerland

关键词: Human;    Mouse;    Pigmentation;    TRP-1;    TRP-2;    Tyrosinase;    TRP;    tyrosinase-related protein;    DOPA;    3;    4-dihydroxyphenylalanine;    DHI;    5;    6-dihydroxyindole;    DHICA;    5;    6-dihydroxyindole-5-carboxylic acid;    Dct;    DOPAchrome tautomerase;    EGF;    epidermal growth factor;    MSH;    melanocyte-stimulating hormone;   

DOI  :  10.1016/0014-5793(96)00109-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Tyrosinase is the key enzyme in pigment synthesis, initiating a cascade of reactions which convert the amino acid tyrosine to the melanin biopolymer. Two other tyrosinase-related proteins (TRP) are known, TRP-1 (probably DHICAoxidase) and TRP-2 (DOPAchrome tautomerase). These proteins show about 40% homology, and recent results have indicated that the genes might be derived from a common ancestor. We will discuss recent findings on genomic organization, and on the proteins and their presumed function, which is important for eumelanin synthesis in mouse and man.

【 授权许可】

Unknown