期刊论文详细信息
FEBS Letters | |
TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture | |
Jackson, I.1  del Marmol, V.2  Berr, P.3  Wakamatsu, K.4  Ghanem, G.2  Ito, S.4  Morandini, R.2  Huez, G.3  Vachtenheim, J.2  | |
[1] MRC Human Genetics Unit, Western Hospital, Edinburgh, Scotland;LOCE - Faculty of Medicine, Université Libre de Bruxelles, Bruxelles, Belgium;Dept. Molecular Biology, Université Libre de Bruxelles, Bruxelles, Belgium;School of Hygiene Fujita Health University, Toyoake Aichi, Japan | |
关键词: Brown; Tyrosinase; Melanogenesis; Human; TRP-1; tyrosinase related protein; DOPA; 3; 4-dihydroxyphenylalanine; DHI; dihydroxyindole; AHP; aminohydroxyphenylalanine; PTCA; pyrrole-2; 3; 5-tricarboxylic acid; SSC; sodium citrate solution; SDS; sodium dodecyl sulfate; TPA; tetradecanoyl-phorbol-13 acetate; IBMX; isobutyl methylxanthine; gp75; glycoprotein 75; | |
DOI : 10.1016/0014-5793(93)81010-W | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.
【 授权许可】
Unknown
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