TRP‐1 expression correlates with eumelanogenesis in human pigment cells in culture

FEBS Letters

Jackson, I.¹  del Marmol, V.²  Berr, P.³  Wakamatsu, K.⁴  Ghanem, G.²  Ito, S.⁴  Morandini, R.²  Huez, G.³  Vachtenheim, J.² 

[1] MRC Human Genetics Unit, Western Hospital, Edinburgh, Scotland;LOCE - Faculty of Medicine, Université Libre de Bruxelles, Bruxelles, Belgium;Dept. Molecular Biology, Université Libre de Bruxelles, Bruxelles, Belgium;School of Hygiene Fujita Health University, Toyoake Aichi, Japan

关键词: Brown;    Tyrosinase;    Melanogenesis;    Human;    TRP-1;    tyrosinase related protein;    DOPA;    3;    4-dihydroxyphenylalanine;    DHI;    dihydroxyindole;    AHP;    aminohydroxyphenylalanine;    PTCA;    pyrrole-2;    3;    5-tricarboxylic acid;    SSC;    sodium citrate solution;    SDS;    sodium dodecyl sulfate;    TPA;    tetradecanoyl-phorbol-13 acetate;    IBMX;    isobutyl methylxanthine;    gp75;    glycoprotein 75;   

DOI  :  10.1016/0014-5793(93)81010-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the relationship in human cultured normal and malignant melanocytes between the accumulation of mRNAs encoding tyrosinase and tyrosinase-related protein-1 (TRP-1), the activity of tyrosinase and the presence of melanin. Tyrosinase mRNA correlates with tyrosinase activity and with the presence of pheomelanin, eumelanin or both melanin types. In contrast TRP-1 mRNA is only detectable in cells containing eumelanin, which suggests a role for TRP-1 in the eumelanin synthesis pathway.

【 授权许可】

Unknown