Interactions between Cytochrome c and DNA Strands Self-Assembled at Gold Electrode

International Journal of Molecular Sciences

Ruojun Lao¹  Lihua Wang¹  Ying Wan¹  Jiong Zhang¹  Shiping Song¹  Zhizhou Zhang²  Chunhai Fan¹ 

[1] Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China, E-mail:;Tianjin University of Science and Technology, Tianjin 300040, China, E-mail:

关键词: Cytochrome c;    DNA;    electrochemistry;    gold electrodes;    cyclic voltammetry;   

DOI  :  10.3390/i8020136

来源: mdpi

【 摘 要 】

In this work, we reported the investigation on the interaction between DNA strands self-assembled at gold electrodes and an electron transfer protein, cytochrome c. We observed that cytochrome c exhibited well-defined electrochemistry in both double-stranded and single-stranded DNA films. This suggested that the electron transfer reaction of cytochrome c arose possibly due to the electron hopping along DNA strands rather than wiring along the double helix. We also compared the heterogeneous electron transfer rate of cytochrome c with that of a ruthenium complex, which further confirmed this mechanism.

【 授权许可】

Unknown   
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