Fluorinated Analogs of Malachite Green: Synthesis and Toxicity

Molecules

George A. Kraus²  Insik Jeon²  Marit Nilsen-Hamilton¹  Ahmed M. Awad¹  Jayeeta Banerjee¹ 

[1] Iowa State University Department of Biochemistry, Biophysics and Molecular Biology, Ames, IA 50011, USA; Tel. [phone]; Fax: [phone];Iowa State University Department of Chemistry, Ames, IA 50011, USA; Tel. [phone]; Fax: [phone]

关键词: Malachite Green;    Malachite Green analogs;    Bathochromic shift;    Toxicity;    Saccharomyces cerevisiae;    human ovarian epithelial cells;   

DOI  :  10.3390/molecules13040986

来源: mdpi

【 摘 要 】

A series of fluorinated analogs of malachite green (MG) have been synthesized and their toxicity to Saccharomyces cerevisiae and a human ovarian epithelial cell line examined. The toxicity profiles were found to be different for these two species. Two analogs, one with 2,4-difluoro substitution and the other with 2-fluoro substitution seem to be the most promising analogs because they showed the lowest toxicity to the human cells.

【 授权许可】

Unknown   
© 2008 by MDPI (http://www.mdpi.org).