A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

Molecules

Muzaffer Alkan¹  Haydar Yüksek¹  Fatih İslamoğlu⁴  Şule Bahi²  Mustafa Calapoğlu¹  Mahfuz Elmastaş³  Hüseyin Akşit³ 

[1] Education Faculty, Kafkas University, 36100 Kars, Turkey; Fax [phone];Fatih Education Faculty, Karadeniz Technical University, 61335 Trabzon, Turkey;Gaziosmanpasa University, Dept. of Chemistry, Tokat, Turkey;Department of Chemistry, Rize University, Rize, Turkey

关键词: 4;    5-Dihydro-1H-1;    2;    4-triazol-5-ones;    Acylation;    Acidity;    Potentiometric titrations;    pK_a;    Antioxidant;   

DOI  :  10.3390/12081805

来源: mdpi

【 摘 要 】

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, ¹H-NMR, ¹³C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pK_a values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(p-methoxybenzoylamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities.

【 授权许可】

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