Synthesis, Acidity and Antioxidant Properties of Some Novel 3,4-disubstituted-4,5-dihydro-1H-1,2,4-triazol-5-one Derivatives

Molecules

Muzaffer Alkan²  Haydar Yüksek¹  Özlem Gürsoy-Kol¹ 

[1] Department of Chemistry, Kafkas University, 36100 Kars, Turkey; E-mail:;Education Faculty, Kafkas University, 36100 Kars, Turkey

关键词: 4;    5-Dihydro-1H-1;    2;    4-triazol-5-ones;    Schiff base;    Acetylation;    Antioxidant activity;    pK_a;    Potentiometric titrations;   

DOI  :  10.3390/molecules13010107

来源: mdpi

【 摘 要 】

3-Alkyl(aryl)-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones 2a-g reacted with4-diethylaminobenzaldehyde to afford the corresponding 3-alkyl(aryl)-4-(4-diethyl-aminobenzylidenamino)-4,5-dihydro-1H-1,2,4-triazol-5-ones 3a-g. The acetylation reactions of compounds 3a-e were investigated and compounds 4a-e were thus obtained. The new compounds were characterized using IR, ¹H-NMR, ¹³C-NMR, UV and MS spectral data. In addition, the newly synthesized compounds 3a-g were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetone and N,N-dimethylformamide (DMF), and the half-neutralization potential values and the corresponding pK_a values were determined for all cases. Moreover, 3 and 4 type compounds were also screened for their antioxidant activities.

【 授权许可】

Unknown   
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