Synthesis of Ring-Contracted Erythromycin A Derivatives via Microwave-Assisted Intramolecular Transesterification

Molecules

Kai Bao¹  Weige Zhang¹  Chuanliang Zhang¹  Yingwei Qu¹  Liang Tian¹  Lan Wu²  Xiang Zhao¹ 

[1] School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, P. R. China;The First Affiliated College, Chinese Medical University, Shenyang 110001, P. R. China

关键词: Ring-contracted derivatives of erythromycin;    transesterification;    microwave irradiation.;   

DOI  :  10.3390/12092123

来源: mdpi

【 摘 要 】

The synthesis of ring-contracted derivatives of erythromycin A via intramolecular transesterification under microwave irradiation of 8,9-anhydro-erythromycin A 6,9-hemiketal and its derivatives is described. It was found that microwave irradiation could significantly improve the yields and shorten the reaction times under either solvent-containing (method A) or solvent-free (method B) conditions.

【 授权许可】

Unknown   
© 2007 by MDPI (http://www.mdpi.org).